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2010 3
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Prognostic significance of ACP5 expression in patients with lung adenocarcinoma.
Gao YL, Liu MR, Yang SX, Dong YJ, Tan XF. Gao YL, et al. Clin Respir J. 2018 Mar;12(3):1100-1105. doi: 10.1111/crj.12637. Epub 2017 Jun 18. Clin Respir J. 2018. PMID: 28398694
This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung adenocarcinoma (AD). ...Using the Kaplan-Meier method, univariate and multivariate regression analysis was to explore the correlation bet …
This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung …
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF. Pin F, et al. Cancer Lett. 2021 Nov 1;520:80-90. doi: 10.1016/j.canlet.2021.06.030. Epub 2021 Jul 4. Cancer Lett. 2021. PMID: 34233150 Free PMC article.
Here we investigated the effects of three non-bone metastatic cancer cachexia models, namely Colon-26 adenocarcinoma (C26), ES-2 ovarian cancer (ES-2), and Lewis lung carcinoma (LLC). Even though C26, ES-2 and LLC tumor growth resulted in comparable weight and muscle loss, …
Here we investigated the effects of three non-bone metastatic cancer cachexia models, namely Colon-26 adenocarcinoma (C26), ES-2 ovarian can …
ACP5, a direct transcriptional target of FoxM1, promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma.
Xia L, Huang W, Tian D, Chen Z, Zhang L, Li Y, Hu H, Liu J, Chen Z, Tang G, Dou J, Sha S, Xu B, Liu C, Ma J, Zhang S, Li M, Fan D, Nie Y, Wu K. Xia L, et al. Oncogene. 2014 Mar 13;33(11):1395-406. doi: 10.1038/onc.2013.90. Epub 2013 Apr 22. Oncogene. 2014. PMID: 23604121
Transwell assays and an orthotopic metastatic model showed that the upregulation of ACP5 promoted HCC invasion and lung metastasis, whereas ACP5 knockdown inhibited these processes. The knockdown of ACP5 significantly attenuated FoxM1-enhanced invasion …
Transwell assays and an orthotopic metastatic model showed that the upregulation of ACP5 promoted HCC invasion and lung metast …
Runt-related transcription factor 1 contributes to lung cancer development by binding to tartrate-resistant acid phosphatase 5.
He C, Bai X, Li Y, Sun H, Kong X, Fu B, Chen L, Zhu K, Li P, Xu S. He C, et al. Cell Cycle. 2019 Dec;18(23):3404-3419. doi: 10.1080/15384101.2019.1678966. Epub 2019 Oct 25. Cell Cycle. 2019. PMID: 31650885 Free PMC article.
Lung cancer (LC) is one of the malignant tumors with growing morbidity and mortality. ...Overexpression of ACP5 promoted malignant biological behavior of LC cells. RUNX1 could bind to ACP5 promoter, and overexpressed RUNX1 promoted ACP5 expression and …
Lung cancer (LC) is one of the malignant tumors with growing morbidity and mortality. ...Overexpression of ACP5 promoted malig …
Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases.
Liu PI, Chang AC, Lai JL, Lin TH, Tsai CH, Chen PC, Jiang YJ, Lin LW, Huang WC, Yang SF, Tang CH. Liu PI, et al. Oncogene. 2021 Feb;40(8):1503-1515. doi: 10.1038/s41388-020-01613-4. Epub 2021 Jan 15. Oncogene. 2021. PMID: 33452455
We also observed that melatonin inhibits RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevents cancer-associated osteoclast differentiation. In lung and prostate bone metastasis models, twice-weekly melaton …
We also observed that melatonin inhibits RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, w …
Tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) as a serum maker for cancer with bone metastasis.
Chao TY, Wu YY, Janckila AJ. Chao TY, et al. Clin Chim Acta. 2010 Nov 11;411(21-22):1553-64. doi: 10.1016/j.cca.2010.06.027. Epub 2010 Jul 1. Clin Chim Acta. 2010. PMID: 20599857 Review.
This review summarizes the development of specific immunoassays for serum TRACP 5b as well as current evidence for its exploitation as a biomarker for diagnosis, treatment response, and prognosis in various cancers with high incidence of bone metastasis including breast, prostate …
This review summarizes the development of specific immunoassays for serum TRACP 5b as well as current evidence for its exploitation as a bio …
Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study.
Urakawa H, Ando Y, Hase T, Kikumori T, Arai E, Maeda O, Mitsuma A, Sugishita M, Shimokata T, Ikuta K, Ishiguro N, Nishida Y. Urakawa H, et al. Int J Cancer. 2020 Jun 15;146(12):3504-3515. doi: 10.1002/ijc.32836. Epub 2019 Dec 28. Int J Cancer. 2020. PMID: 31846063 Free article.
Sixty-seven patients were analyzed. The primary tumor sites were 21 lung, 16 breast and 30 others. Forty and 27 patients were treated with Denosumab and Zoledronic acid, respectively. ...Our study showed that early posttreatment ICTP is useful for predicting BD progression …
Sixty-seven patients were analyzed. The primary tumor sites were 21 lung, 16 breast and 30 others. Forty and 27 patients were treated …
microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity.
Bai X, He C, Fu B, Kong X, Bu J, Zhu K, Zheng W, Zhou F, Ni B. Bai X, et al. Cell Cycle. 2020 Dec;19(23):3260-3276. doi: 10.1080/15384101.2020.1839697. Epub 2020 Nov 23. Cell Cycle. 2020. PMID: 33222607 Free PMC article.
However, the role of miR-877 in NSCLC as it relates to tartrate resistant acid phosphatase 5 (ACP5) is unknown. For this study, the gain-and-loss-of-function experiments were performed to explore the effects of miR-877 and ACP5 on NSCLC. miR-877 expression in LC and …
However, the role of miR-877 in NSCLC as it relates to tartrate resistant acid phosphatase 5 (ACP5) is unknown. For this study, the g …
Clinical significance of serum BAP, TRACP 5b and ICTP as bone metabolic markers for bone metastasis screening in lung cancer patients.
Tang C, Liu Y, Qin H, Li X, Guo W, Li J, Wang W, Qu L, Hu H, Xu C, Zheng L, Huang Y, Liu B, Gao H, Halleen JM, Liu X. Tang C, et al. Clin Chim Acta. 2013 Nov 15;426:102-7. doi: 10.1016/j.cca.2013.09.011. Epub 2013 Sep 19. Clin Chim Acta. 2013. PMID: 24055775
BACKGROUND: We investigated the clinical significance of serum bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) and type I collagen carboxyterminal telopeptide (ICTP) as bone metabolic markers for bone metastasis (BM) screening i …
BACKGROUND: We investigated the clinical significance of serum bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase …
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Wu Q, Tian Y, Zhang J, Tong X, Huang H, Li S, Zhao H, Tang Y, Yuan C, Wang K, Fang Z, Gao L, Hu X, Li F, Qin Z, Yao S, Chen T, Chen H, Zhang G, Liu W, Sun Y, Chen L, Wong KK, Ge K, Chen L, Ji H. Wu Q, et al. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3978-E3986. doi: 10.1073/pnas.1716589115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632194 Free PMC article.
Lung cancer is the leading cause of cancer-related death worldwide. ...From individual knockout of 55 potential TSGs, we identify five genes, including Utx, Ptip, Acp5, Acacb, and Clu, whose knockout significantly promotes lung tumorigenesis. ...
Lung cancer is the leading cause of cancer-related death worldwide. ...From individual knockout of 55 potential TSGs, we identify fiv …
13 results